Clinical effect of Esomeprazole in the treatment of upper gastrointestinal bleeding caused by peptic ulcer
艾司奥美拉唑治疗消化性溃疡致上消化道出血的临床效果研究

摘要

目的:探讨在因消化性溃疡所致上消化道出血病症治疗中以艾司奥美拉唑治疗，对改善临床症 状及提高患者预后质量的治疗意义。方法:试验所选择对象是在 2019.04 至 2022.02 此阶段内，在本院治疗的 因消化性溃疡而出现上消化道出血症状病患数量共计 78 例，采取随机数字表法分组，一组设为对照组，病 例数共 39 例，采用采用奥美拉唑施治，另一组设为观察组，组间病患数量为 39 例，采用艾司奥美拉唑施 治，统计施治后组间总疗效、临床相关指标及用药安全性各项治疗指标差异。结果:观察组病患施治疗效比 对照组病患高，观察组病患出血量、平均止血时间、潜血转阴时间及住院时间比对照组病患低，观察组病 患生活质量评分比对照组病患高 P＜0.05；两组用药不良反应无显著性差异，P＞0.05。结论:以艾司奥美拉 唑施治，可有效对患者出血症状及腹痛症状进行缓解，进一步提升施治疗效的同时，还能缩短其住院时间， 用药安全性较高，适宜基层医院借鉴应用。

Abstract

Objective: To explore the therapeutic significance of esomeprazole in the treatment of upper gastrointestinal bleeding caused by peptic ulcer in improving clinical symptoms and improving the quality of prognosis of patients.
Methods: Test the selected object is from 2019.04 to 2022.02, in this stage in our hospital treatment for peptic ulcer and a total of 78 cases of patients with symptoms of upper gastrointestinal hemorrhage quantity, take a random number table method of grouping, a set of set as control group, the number of cases, a total of 39 cases, the adoption omeprazole, providing another group set as observation group, patients of 39 cases number between groups, Esomeprazole was used for treatment, and the differences of total efficacy, clinical related indicators and medication safety indicators among the groups after treatment were analyzed.
Results: The therapeutic effect of observation group was higher than that of control group, the amount of blood loss, mean hemostasis time, occult blood conversion time and hospitalization time of observation group were lower than that of control group, and the quality of life score of observation group was higher than that of control group, P < 0.05; There was no significant difference in adr between the two groups, P > 0.05.
Conclusion  : Esomeprazole can effectively relieve the symptoms of bleeding and abdominal pain in patients, further improve the therapeutic effect, but also shorten the length of hospital stay, high drug safety, suitable for primary hospitals to use for reference.