Comprehensive nursing analysis of patients with refractory recurrent multiple myeloma treated with chimeric antigen receptor T cells (CAR-T)
嵌合抗原受体T细胞(CAR-T)治疗难治复发的多发性骨髓瘤综合护理分析

摘要

目的 分析在嵌合抗原受体T细胞（CAR-T）治疗难治复发的多发性骨髓瘤患者中开展综合护理的临床效果。方法 本次研究选取在我院接受治疗的多发性骨髓瘤患者60例，根据随机数字表法分成两组，组别为观察组和对照组，每组各有患者30例，两组患者均接受嵌合抗原受体T细胞（CAR-T）治疗，同时给予对照组常规护理，给予观察组综合护理，对比并分析两组护理治疗效果。结果 观察组患者的焦虑情绪和依从性改善效果优于对照组，并发症发生率低于对照组，疼痛程度轻于对照组，最终生活质量与对照组相比明显提高，（P<0.05）。结论 将综合护理应用于多发性骨髓瘤患者CAR-T治疗管理中，可增强患者的身心舒适度与配合度，减少并发症发生，提高疾病控制效果及生活质量。

Abstract

Objective To analyze the clinical effect of comprehensive care in patients with refractory recurrent multiple myeloma treated with chimeric antigen receptor T cells (CAR-T).
Methods In this study, 60 patients with multiple myeloma who received treatment in our hospital were selected and divided into two groups according to random number table method: observation group and control group, with 30 patients in each group. Patients in both groups received chimeric antigen receptor T cell (CAR-T) therapy, and routine care was given to the control group while comprehensive care was given to the observation group. The nursing treatment effect of the two groups was compared and analyzed.
Results The improvement effect of anxiety and compliance in the observation group was better than that in the control group, the complication rate was lower than that in the control group, the pain degree was less than that in the control group, and the final quality of life was significantly improved compared with the control group (P<0.05).
Conclusion   The application of comprehensive nursing in CAR-T therapy management of multiple myeloma patients can enhance the physical and mental comfort and cooperation of patients, reduce the occurrence of complications, and improve the effect of disease control and quality of life.