The effect of different doses of aspirin and poliovirus on platelet aggregation function in aspirin-resistant patients and their care
不同剂量阿司匹林和波立维对阿司匹林抵抗患者血小板聚集功能的影响及护理

摘要

目的 分析不同剂量阿司匹林和波立维对阿司匹林抵抗患者血小板聚集功能的影响及护理效果。方法 挑选医院两年期间治疗的阿司匹林抵抗患者（样本纳入时间：2021.07月至2024.07月；样本纳入例数：84例）当作研究对象，利用数字表随机排序法进行分组，划分为对照组（100mg阿司匹林+波立维治疗联合常规护理，n=42）与研究组（300mg阿司匹林+波立维治疗联合循证护理，n=42）。对比两组的血小板聚集功能、用药依从性、自我效能及生活质量。结果 在二碳酸腺苷诱导下血小板聚集率与花生四烯酸诱导下血小板聚集率上，两组对比无显著差异（P＞0.05）。在用药依从性、自我效能评分及生活质量评分上，研究组高于对照组（P＜0.05）。结论 不同剂量阿司匹林+波立维对改善阿司匹林抵抗患者血小板聚集功能的作用相当，配合循证护理能提高用药依从性，改善生活质量，临床可进一步推广应用。

Abstract

Objective To analyze the effects of different doses of aspirin and Plavix on platelet aggregation function and nursing effect in patients with aspirin resistance.
Methods Patients with aspirin resistance treated in the hospital during two years (sample inclusion time: July 2021 to July 2024; sample inclusion number: 84 cases) were selected as research subjects and divided into control group (100 mg aspirin + Plavix treatment combined with routine care, n=42) and study group (300 mg aspirin + Plavix treatment combined with evidence-based care, n=42). The platelet aggregation function, medication compliance, self-efficacy and quality of life of the two groups were compared.
Results There was no significant difference between the two groups in the platelet aggregation rate induced by adenosine dicarbonate and the platelet aggregation rate induced by arachidonic acid (P＞0.05). The study group had higher scores in medication compliance, self-efficacy and quality of life than the control group (P < 0.05).
Conclusion   Different doses of aspirin + Plavix have similar effects on improving platelet aggregation function in patients with aspirin resistance. Evidence-based nursing can improve medication compliance and quality of life, and can be further promoted and applied in clinical practice.