Observation and analysis of 1 case of convulsion caused by aminophylline and dihydroxyproprofylline
氨茶碱及二羟丙茶碱致患者惊厥 1 例观察与分析

摘要

目的 分析氨茶碱及二羟丙茶碱在慢性阻塞性肺疾病治疗过程中导致惊厥的临床特点，为茶碱类注 射剂合理安全应用提供参考。方法：通过参与 1 例慢性阻塞性肺疾病患者的临床治疗，护理中发现患者出现惊厥， 根据惊厥特点、患者既往史、用药史，分析可能发生的原因，协助医生治疗。结果：根据患者既往病史，排除患 者由癫痫等疾病引起惊厥的可能；患者近期所用药物只有茶碱类有惊厥的不良反应，停止应用茶碱类药物后患者 惊厥再未发生，故确定惊厥由茶碱类药物导致。结论：茶碱类药物治疗窗窄，代谢方面个体差异大，使用时不注 意影响血药浓度的各种因素，容易引起惊厥等严重的不良反应。

Abstract

Objective To analyze the clinical characteristics of aminophylline and dihydroxyproprofylline in the treatment of chronic obstructive pulmonary disease causing convulsions, and to provide reference for the rational and safe application of theophylline injections.
Methods By participating in the clinical treatment of a patient with chronic obstructive pulmonary disease, the patient was found to have convulsion during nursing. According to the characteristics of convulsion, the patient's past history and medication history, the possible causes were analyzed to assist the doctor in treatment.
Results According to the patient's history, the possibility of convulsion caused by epilepsy and other diseases was excluded. Only theophylline drugs were used in the patient recently, and convulsions did not occur after stopping the use of theophylline drugs, so it was determined that the convulsions were caused by theophylline drugs.
Conclusion   Theophylline drugs have narrow therapeutic window, large individual differences in metabolism, and are easy to cause severe adverse reactions such as convulsion when used without paying attention to various factors affecting blood concentration.