摘要
目的 分析成年血友病 A 患者合并关节畸形的危险因素，并为其有效防治提供对策。方法 回顾性收
集分析广州某三甲医院血友病中心 2022 年 3 月至 2023 年 9 月初诊登记的 145 例成年血友病 A 患者一般资料及临
床资料，收集患者关节畸形情况并进行关节畸形危险因素 Logistic 分析，提出防治对策。结果 共有 102 例（70.34%）
患者合并关节畸形，单因素分析显示，患者 BMI、首次出血年龄、既往出血关节数≥3 个及近一年出血次数>20
次 4 个变量是患者合并关节畸形的危险因素。Logistic 回归分析显示，年龄、首次出血年龄及近一年出血次数>20
次是患者合并关节畸形的独立危险因素。结论 血友病患者合并关节畸形的危险因素较多，医护人员应加强患者
管理及健康教育，制定规范的治疗方案及护理干预措施，改善患者关节健康状况，提高患者生活质量。
关键词： 血友病；关节畸形；分析；对策
Abstract
Objective To analyze the risk factors of joint deformities in adult hemophilia A patients and provide
effective prevention and treatment strategies. Method A retrospective analysis was conducted on the general and clinical
data of 145 adult hemophilia A patients who were initially diagnosed and registered at a hemophilia center in a third tier
hospital in Guangzhou from March 2022 to September 2023. The joint deformities of the patients were collected and
logistic analysis was conducted on the risk factors for joint deformities, and prevention and treatment strategies were
proposed. Results A total of 102 patients (70.34%) had joint deformities. Univariate analysis showed that four variables,
including patient BMI, age of first bleeding, number of previously bleeding joints ≥3, and number of bleeding
episodes>20 in the past year, were risk factors for joint deformities in patients. Logistic regression analysis showed that
age, age of first bleeding, and number of bleeding episodes>20 in the past year are independent risk factors for patients
with joint deformities. Conclusion There are many risk factors for hemophilia patients with joint deformities. Medical
staff should strengthen patient management and health education, develop standardized treatment plans and nursing
interventions, improve the joint health status of patients, and improve their quality of life.
Key words： Hemophilia; Joint deformities; Analysis; countermeasure
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