Clinical application of pituitrin in pulmonary puncture biopsy for the prevention of bleeding
垂体后叶素在肺穿刺活检预防出血的临床应用

摘要

目的 研究分析垂体后叶素在肺穿刺活检预防出血的临床应用效果。方法 选取 2018 年 1 月-2021 年 1 月期间于我院介入科进行肺穿刺活检术 316 例患者作为研究对象，采用电脑随机数字排序法将其分为实验组与 对照组，每组各 158 例，所有患者均进行 CT 引导下肺穿刺活检术，给予对照组患者氨甲环酸进行出血预防，给 予实验组患者垂体后叶素进行出血预防。最后比较两组患者的临床治疗有效率、不良反应发生情况以及出血并发 症发生率。结果 ①经比较，实验组与对照组两组患者的临床治疗有效率分别为 96.20%与 66.46%，由此可见，实 验组患者的临床治疗有效率明显高于对照组，数据有明显差异（P＜0.05）具有统计学意义；②经比较，实验组 患者的不良反应发生率为 18.35%明显低于对照组患者 41.48%的不良反应发生率，数据有明显差异（P＜0.05）具 有统计学意义；③经比较，实验组患者的出血并发症发生率明显低于对照组，数据有明显差异（P＜0.05）具有 统计学意义。结论 给予进行肺穿刺活检术的患者垂体后叶素，能够显著提升治疗有效率与降低不良反应发生率， 应用效果良好，值得推广。

Abstract

Objective To study and analyze the clinical application effect of pituitrin in lung biopsy to prevent bleeding. Method A total of 316 patients who underwent lung puncture biopsy in the Interventional department of our hospital from January 2018 to January 2021 were selected as the study objects, and were divided into experimental group and control group by computer random number sequencing method, with 158 cases in each group. All patients underwent CT-guided lung puncture biopsy, and control group was given tranexamic acid for bleeding prevention. Patients in the experimental group were given pituitrin for bleeding prevention. Finally, the clinical efficacy, the occurrence of adverse reactions and the incidence of bleeding complications were compared between the two groups.
Results ① After comparison, the clinical effective rate of the experimental group and the control group was 96.20% and 66.46%, respectively. It can be seen that the clinical effective rate of the experimental group was significantly higher than that of the control group, and the data were significantly different (P<0.05) with statistical significance; ② After comparison, the incidence of adverse reactions in the experimental group (18.35%) was significantly lower than that in the control group (41.48%), with significant difference (P<0.05). ③ After comparison, the incidence of bleeding complications in the experimental group was significantly lower than that in the control group, and the data were significantly different (P<0.05) with statistical significance.
Conclusion   The administration of pituitrin in patients undergoing lung puncture biopsy can significantly improve the effective rate of treatment and reduce the incidence of adverse reactions, and the application effect is good, worthy of promotion.