Study on the influence of different decocting methods on the components of Maxing Shigan Decoction
不同煎煮方法对麻杏石甘汤中成分的影响探究

摘要

目的 探究不同煎煮方法对麻杏石甘汤中成分的影响。方法 选择不同的煎煮方法熬制麻杏石甘汤， 分别取得其中的伪麻黄碱、麻花碱、甘草苷、苦杏仁等成分，以 HOLC 法对不同煎煮法取得的含量进行测定，选 择 ICP-ASE 测定金属元素，比较不同煎煮方法中麻杏石甘汤中成分的区别，判断其药效成分。结果 不同煎煮方 法对麻杏石甘汤中成分有所影响，先煎麻黄和麻黄石膏，其中的麻黄碱和伪麻黄碱成分明显高于合煎、先煎石膏， 其差异具有统计学意义（P＜0.05）。结论 为保障药效，最佳方法为先行煎煮麻黄石膏，不仅能够最大程度保留 药性，还有利于麻杏石甘汤中微量元素的溶出，从而起到更好的临床治疗效果。

Abstract

Objective To explore the effects of different decocting methods on the components of Maxing Shigan Decoction.
Methods Different decocting methods were selected to prepare Maxing Shigan Decoction, and pseudoephedrine, fried dough twist alkaloid, glycyrrhizin, bitter almond and other components were obtained respectively. The contents obtained by different decocting methods were determined by HOLC method, and the metal elements were determined by ICP-ASE.
Results Different decocting methods have some effects on the components of Maxing Shigan Decoction. The components of ephedrine and pseudoephedrine in ephedrine and ephedrine gypsum decocted first are significantly higher than those decocted together and decocted first, with statistical significance (P<0.05).
Conclusion   In order to ensure the efficacy, the best method is to decoct ephedra gypsum first, which can not only retain the drug properties to the maximum extent, but also facilitate the dissolution of trace elements in Maxing Shigan Decoction, so as to play a better clinical treatment effect.