Application of combined detection of parathyroid hormone, urea nitrogen and creatinine in early diagnosisof renal failure.
甲状旁腺激素、尿素氮与肌酐联合检测在肾功能衰竭早期诊断中应用

摘要

目的 探究在肾功能衰竭早期诊断中给予甲状旁腺激素、尿素氮与肌酐联合检测的关联性及临 床应用价值。方法 选择 2021 年 5 月至 2022 年 8 月期间我院收治的肾功能衰竭早期患者 120 例为本次研究 对象，设为实验组，并根据疾病分期在实验组下分设代偿期组（n=29）、氮质血症期组（n=41）、尿毒症 期组（n=50）三个亚组，同时随机抽取同期间于我院行身体检查的健康者 120 例为对照组，两组均给予甲 状旁腺激素、尿素氮与肌酐联合检测，对比两组检查结果和实验组各亚组各项指标水平特征，分析甲状旁 腺激素、尿素氮与肌酐指标与早期肾功能衰竭及分期的关联性。结果 和对照组相比，实验组的甲状旁腺激 素、尿素氮与肌酐水平均呈显著增高状态，差异存在统计学意义（P<0.05）；在实验组各亚组中，代偿期组、 氮质血症期组、尿毒症期组的各项指标水平依次呈增高趋势发展，且对比差异存在统计学意义（P<0.05）。 结论 在肾功能衰竭早期诊断中应用甲状旁腺激素、尿素氮与肌酐联合检测具有切实意义，可用于辅助疾病 临床早期诊断，并帮助分析疾病发展程度，为临床治疗提供科学有效参考。

Abstract

objective to explore the correlation and clinical value of combined detection of parathyroid hormone, urea nitrogen and creatinine in the early diagnosis of renal failure.
Methods 120 patients with early renal failure treated in our hospital from May 2021 to August 2022 were selected as the experimental group. according to the stage of the disease, the patients were divided into three groups: compensatory group (n = 29), azotemia group (n = 41) and uremia group (n = 50). 120 healthy subjects who underwent physical examination in our hospital during the same period were selected as the control group. The examination results of the two groups and the level characteristics of various indexes in each subgroup of the experimental group were compared.
Results the levels of parathyroid hormone, urea nitrogen and creatinine in the experimental group were significantly higher than those in the control group (P < 0.05), and the levels of parathyroid hormone, urea nitrogen and creatinine in the experimental group were significantly higher than those in the control group (P < 0.05). The levels of various indexes in compensatory group, azotemia group and uremia group showed an increasing trend (P < 0.05).
Conclusion   the combined detection of parathyroid hormone, urea nitrogen and creatinine in the early diagnosis of renal failure is of practical significance, which can be used to assist the early clinical diagnosis of the disease and help to analyze the degree of disease development. to provide scientific and effective reference for clinical treatment.