摘要
目的：分析痛风发作用四黄水蜜外敷疗法的价值。方法：对2021 年4 月-2022 年4 月本科接
诊痛风发作病人（n=74）进行随机分组，试验和对照组各 37 人，前者采取四黄水蜜外敷疗法，后者行常规
治疗。对比不良反应等指标。结果：关节总有效率，试验组的数据97.3%，和对照组81.08%相比更高（P＜
0.05）。关于不良反应，试验组的发生率 0，和对照组 16.22%相比更低（P＜0.05）。关于肿瘤坏死因子-α，
疗程结束之时：试验组的数据（5.31±1.04）ng/ml，和对照组（19.37±4.68）ng/ml 相比更低（P＜0.05）。关
于 sf-36 评分，疗程结束之时：试验组的数据（88.51±3.64）分，和对照组（79.22±4.73）分相比更高（P＜
0.05）。结论：痛风发作用四黄水蜜外敷疗法，效果显著，病人的预后也更好，不良反应更少，炎性因子改
善更加明显。
关键词： 痛风发作；价值；四黄水蜜；不良反应
Abstract
Objective: To analyze the value of external application of Sihuang water honey in the treatment
of gout. Methods: Patients with gout attack (n=74) were randomly divided into experimental group and control
group from April 2021 to April 2022. The former was treated with external application of Sihuang water honey,
and the latter was treated with routine treatment. Adverse reactions and other indicators were compared. Results:
the total effective rate of the test group was 97.3%, which was higher than that of the control group (81.08%) (P <
0.05). As for adverse reactions, the incidence of the test group was 0, lower than that of the control group (16.22%)
(P < 0.05). About tumor necrosis factor- α， At the end of the course of treatment: the data of the experimental
group was (5.31 ± 1.04) ng/ml, which was lower than that of the control group (19.37 ± 4.68) ng/ml (P < 0.05). In
terms of SF-36 score, at the end of treatment, the score of the experimental group (88.51±3.64) was higher than that
of the control group (79.22±4.73) (P < 0.05). Conclusion : The effect of gout is remarkable, the prognosis of
patients is better, the adverse reaction is less, and the improvement of inflammatory factors is more obvious.
Key words： Gout attack; Value; Four yellow water honey; Adverse reactions
参考文献 References
[1] 崔晓艳,凌敬,赖桂艳. 四黄水蜜散治疗痛风急性发作的疗效观察[J]. 中国现代药物应用,2021,15(11):223-225.
[2] 邓丽玲,冯恩辉,徐少硕. 四黄水蜜外敷治疗痛风性关节炎急性发作的疗效分析[J]. 世界最新医学信息文摘（连续型电子期刊）,2019,19(96):214,218.
[3] 覃花桃,王宁莉,梁秋叶. 中药四黄水蜜外敷治疗急性痛性关节炎的疗效观察[J]. 右江医学,2017,45(2):168-171.
[4] 周厚明,陈树清,孙保国,等. 四黄水蜜外敷合加味四妙散内服治疗急性痛风性关节炎的临床研究[J]. 中药材,2007,30(9):1196-1198.
[5] 孙楠. 中药四黄水蜜外敷治疗急性痛风性关节炎的疗效及护理探讨[J]. 商情,2019(30):294.
[6] 戴顺姿,胡祝女,汪巧玉,等. 新癀片加四黄粉水蜜调敷联合心理干预治疗痛风性关节肿痛的临床研究[J]. 基层医学论坛,2021,25(30):4315-4317.
[7] 胡英. 四黄水蜜外敷治疗急性痛风性关节炎的疗效及护理探讨[J]. 按摩与康复医学,2018,9(14):62-63.
[8] 李焕梅,赵彩伶,曾瑞峰,等. 外用四黄制剂治疗急性痛风性关节炎的系统评价与 Meta 分析[J]. 岭南急诊医学杂志,2022,27(2):175-180.
[9] 倪角角,张靓. 四黄水蜜膏外敷治疗急性痛风性关节炎临床观察及护理[C]. //第七届全国中西医结合骨科微创学术年会论文集. 2017:515-518.
[10] 郑炜. 中西医结合治疗痛风性关节炎研究进展[J].2021,(15).
[11] 江涛,樊丽红,王恒龙,等 层医院痛风规范化诊疗中超声检查作用评估 . 中国药物与临床, 2020 ,20 (2) :236-238
[12] 宋述灵,陈燕,孔娟,等 护理干预在急性痛风性关节炎护理中的效果分析 . 心血管外科杂志（电子版）, 2020 ,9 (1) :223
[13] 段登海,袁媛,申云杰,等 中药外敷联合秋水仙碱治疗急性痛风性关节炎经验举隅 . 中国民族民间医药, 2020 ,29 (21) :86-87
[14] 黄刚,梁旭 刺络放血联合水调散外敷治疗急性痛风性关节炎临床观察 . 辽宁中医药大学学报, 2020 ,22 (6) :177-180
[15] 向珍蛹,叶敏谊,邓钰敏,等 双柏散外敷联合针灸治疗急性痛风性关节炎临床疗效观察 . 中医药临床杂志, 2018 ,30 (9) :1699-1702
[16] 梁汉坚,彭自强,钟康华,等 刺血疗法联合四黄清热散外敷治疗急性痛风性关节炎的临床研究 . 中国医药科学, 2022 ,12 (3) :83-86
[17] 王珂,马志毅 针刺配合中药外敷治疗无高尿酸血症的急性痛风性关节炎 35 例疗效观察 . 湖南中医杂志, 2018 ,34 (5) :114-115
[18] 程巨萍 清胰汤、大柴胡汤鼻饲联合中药灌肠治疗肝郁气滞及肝胆湿热证急性胰腺炎的疗效评价 . 浙江中医杂志, 2020 ,55 (3) :181-183